2. Apoptosis Immunology/Inflammation
  3. TNF Receptor CD20
  4. Belimumab

Belimumab  (Synonyms: 贝利尤单抗; LymphoStat B)

目录号: HY-P9952 纯度: 99.40%
COA

摩尔计算器

Belimumab (LymphoStat B) 是一种人源化抗 B 淋巴细胞刺激因子 (BLyS) 蛋白的 IgG1λ 单克隆抗体。Belimumab 在自身免疫性疾病和 B 淋巴细胞恶性肿瘤中拮抗 BLyS 活性。Belimumab 可用于系统性红斑狼疮 (SLE) 研究。

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CAS No. : 356547-88-1

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5 mg ￥1200
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10 mg ￥2000
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Belimumab 相关抗体

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Belimumab (LymphoStat B) is a humanized IgG1λ monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research[1][2][3][4].

同型

Human IgG1 lambda
推荐同型对照抗体
种属

Human
体内研究
(In Vivo)

Belimumab (5, 15 或 50 mg/kg, 静脉注射, 每 2 周 1 次，持续 13 或 26 周) 降低食蟹猴外周血 CD20+ B 淋巴细胞[3]。

单剂量 Belimumab 在食蟹猴体内的药代动力学[3]

Parameters Cmax (μg/mL) AUC0-∞ (day μg/mL) V1 (mL/kg) Vss (mL/kg) CL (mL/day/kg) T1/2,α (day) T1/2,term (day) MRT (day)
5 mg/kg (n=4) 111±2 901±40 45.0±0.7 85.0±2.1 5.6±0.2 0.52±0.13 11.2±0.7 15.4±1.0
50 mg/kg (n=3) 1230±180 8970±320 42.4±5.9 108±14 5.6±0.2 0.44±0.20 14.0±1.8 19.1±2.1
150 mg/kg (n=3) 3778±326 22,693±3990 39.7±3.3 89.8±11.4 6.8±1.3 0.41±0.55 11.5±1.7 13.7±3.5

Belimumab 在雄性和雌性食蟹猴体内每周 4 次静脉注射后的药代动力学[3]
Parameters Cmax (μg/mL) AUC0-∞ (day μg/mL) V1 (mL/kg) Vss (mL/kg) CL (mL/day/kg) T1/2,α (day) T1/2,term (day) MRT (day)
5 mg/kg (n=4) 102±14 717±129 49.7±6.8 126±18 7.2±1.5 0.71±0.26 13.5±1.8 17.8±2.5
50 mg/kg (n=4) 313±38 2365±501 48.4±6.2 108±10 6.5±1.2 1.29±0.61 14.0±3.1 17.0±4.2
150 mg/kg (n=4) 1064±190 9286±1809 48.0±7.8 106±18 5.5±1.1 0.77±0.16 14.6±2.2 19.4±3.5

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Healthy cynomolgus monkeys[3]
Dosage: 5, 15 or 50 mg/kg
Administration: peripheral vein injection, once every 2 weeks for 13 or 26 weeks
Result: Dose-dependently decreased circulating peripheral blood B lymphocytes persisted through at least week 39 and in some monkeys longer despite cessation of treatment at week 26.
Clinical Trial
CAS 号
性状

固体

颜色

White to off-white

中文名称

贝利木单抗； 贝利尤单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
纯度 & 产品资料

纯度: 99.40%

COA (264 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Belimumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Belimumab356547-88-1LymphoStat B贝利木单抗 贝利尤单抗TNF ReceptorCD20Tumor Necrosis Factor ReceptorTNFRhumanizedIgG1λ monoclonal antibodyB-lymphocyte stimulatorautoimmune diseasesB-lymphocyte malignanciesSLEInhibitorinhibitorinhibit

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